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John M. Kirkwood, MD

  • Director of the Melanoma Center at UPMC Hillman Cancer Center
  • Usher professor of medicine, dermatology, and clinical and translational science at the University of Pittsburgh School of Medicine and the Clinical Translational Science Institute at the University of Pittsburgh.

Dr. Kirkwood received his medical degree in 1973 from Yale University and completed postgraduate work at Yale-New Haven Hospital and Harvard University. He joined the University of Pittsburgh Cancer Institute in 1986 as director of the Melanoma Center and as professor and chief of the Division of Medical Oncology at the University of Pittsburgh School of Medicine.

In 1996, he was named vice chairman for clinical research in the University of Pittsburgh School of Medicine.

Dr. Kirkwood’s research has focused on melanoma, a cancer that kills more than 7,000 people in the United States each year. Under Dr. Kirkwood’s direction, the Melanoma Center has developed new and effective treatment approaches for this disease. He has received international acclaim for leading a multicenter study developed on the basis of his pioneering work with biological treatments for melanoma that has provided the first adjuvant, or additional, therapy for treating patients with high-risk melanoma, a type likely to recur despite surgery.

In addition, Dr. Kirkwood is leading a number of highly promising clinical trials with cancer vaccines, using biological response modifiers, naturally produced substances, to spur the body’s own immune system into recognizing and destroying melanoma.

Dr. Kirkwood also conducts basic research on the molecular and biological changes normal moles undergo as they transform into melanoma. These studies are aimed at providing earlier detection methods and means to prevent this cancer.